Silver nanoparticle induced muscle abnormalities : A sub-chronic dermal assessment in guinea pig

Nanosilver has recently been recognized as an antimicrobial agent. Although this nanoparticlecan be used in medical applications but its dermal and systemic toxicity via dermal exposure hasnot been completely determined yet. The aim in this study was to investigate the potential dermaltoxicity of Nanosilver in subchronic method. Before the colloidal silver nanoparticle toxicityevaluation, their size was subjected in sizes < 100 nm by Transmission Electron Microscopeand revealed that the nanoparticles contained nanosilver by X-Ray Diffraction. The selectedanimals were 24 male guinea pigs weighing 350-400 g. These animals were exposed to threeconcentrations of nanosilver (100, 1000 and 10000 μg/ml) by dermal exposure. Toxic responseswere assessed based on histopathologic parameters. Significant dose-dependent histopathologicalchanges were observed in the muscle of treated animals. It seems that colloidal silvernanoparticles have the ability to create dose-dependent toxic responses in this organ.